Genetics and Epigenetics Pathogenesis of Behçet’s Syndrome

Vasculitides are a group of diseases characterized by inflammation and destruction of blood vessel wall during the disease course. The disease itself exhibit non-specific signs and symptoms as well as differences in patho physiology, vessel involvement, and demographics [1]. Complexity of the disease related to the structural and function of the vessel, the tissue, and the associated microenvironment involved in the disease [2]. Behçet’s syndrome (BS) is a vasculitides, which is also characterized numerous systemic manifestations, including oral aphthous ulcers, skin lesions, ocular diseases, neurologic diseases, rheumatologic diseases, gastrointestinal disease and genital ulcers. These clinical manifestations of BS are present mainly due to the inflammation of the blood vessels and it is known for its ability to affect both, arteries and the veins. However, the etiology of BS is only partially understood, and previous studies have demonstrated a role of genetic and epigenetic factors contributes to disease pathophysiology. Jibran Sualeh Muhammad1* and Muhammad Ishaq2 1Department of Biological and Biomedical Sciences, The Aga Khan University, Pakistan 2Department of Internal Medicine, Jinnah Medical College Hospital, Pakistan *Corresponding author: Jibran Sualeh Muhammad, Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi 74800, Pakistan. Tel: +922134864435, +923342811050; Email: [email protected]